Drug
Name |
Brand Names |
Drug Class |
Indications |
Mechanism of
Action |
Arformoterol
tartrate |
Brovana |
Long-Acting
beta-2 adrenergic agonist (LABA); Bronchodilator |
Chronic
Obstructive Pulmonary Disease |
Selective
long-acting beta-2 adrenergic receptor agonist, which produces relaxation of
bronchial smooth muscle fibers leading to bronchodilation. It is the
(R,R)-entantiomer of formoterol, and has a two-fold greater potency of
racemic formoterol. |
Bitolterol
mesylate* |
* Tornalate (No
longer available in the United States) |
Long-Acting
beta-2 adrenergic agonist (LABA); Bronchodilator |
Asthma;
COPD (off-label) |
|
Formoterol
fumarate |
Foradil
Aerolizer; Perforomist |
Long-Acting
beta-2 adrenergic agonist (LABA); Bronchodilator |
Asthma;
Exercise induced asthma prophylaxis; COPD |
Selective
long-acting beta-2 adrenergic agonist which causes an increase in cyclic-AMP
by stimulating intracellular adenyl cyclase. This action results in smooth
muscle relaxation and inhibition of inflamatory mediators. |
Salmeterol
xinafoate |
Serevent Diskus;
Serevent HFA |
Long-Acting
beta-2 adrenergic agonist (LABA); Bronchodilator |
Asthma;
Exercise induced asthma prophylaxis; COPD |
Selectively
stimulates the beta-2 adrenergic receptors of intracellular adenyl cyclase,
the catalyst for the conversion of adenosine triphosphate (ATP) to
cyclic-1’,5’-adenosine monophosphate (cyclic AMP). This action causes an
increase in cyclic AMP levels resulting in bronchial smooth muscle
relaxation, and inhibition of the release of immediate hypersensitivity
mediators from the mast cells. |
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