| Ipratropium
bromide |
Atrovent, Atrovent HFA |
Anticholinergic;
Bronchodilator |
Chronic
Obstructive Pulmonary Disease; Nasal discharge; Asthma exacerbation
(off-label) |
Antagonist of
acetylcholine resulting in decreased levels of cyclic guanosine monophosphate
(cyclic-GMP) leading to bronchial smooth muscle relaxation and
bronchodilation. Ipratropium bromide also has antisecretory properties that
inhibit the serous and seromucous glands within the nasal mucosa. |
| Tiotropium
bromide |
Spiriva |
Anticholinergic;
Bronchodilator |
Chronic
Obstructive Pulmonary Disease |
Tiotropium
bromide is actually an antimuscarinic agent, although it is often refered to
as an anticholinergic. A long acting antagonist of acetylcholine resulting in
decreased levels of cyclic guanosine monophosphate (cyclic-GMP) leading to
bronchial smooth muscle relaxation and bronchodilation. Tiotropium also has
antisecretory properties that inhibit the serous and seromucous glands within
the nasal mucosa. |